This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for QPRT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QPRT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QPRT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,594,581–29,595,807 | 67.9 kb | Distal (>10kb) Multiome | 486 | |
| chr16:29,613,063–29,614,058 | 49.6 kb | Distal (>10kb) Multiome | 302 | |
| chr16:29,614,664–29,615,288 | 48.3 kb | Distal (>10kb) Multiome | 247 | |
| chr16:29,666,524–29,667,045 | 3.5 kb | Proximal (<10kb) Multiome | 338 | |
| chr16:29,678,867–29,679,831 | 15.9 kb | Distal (>10kb) Multiome | 783 | |
| chr16:29,708,839–29,709,431 | 45.8 kb | Distal (>10kb) Multiome | 96 | |
| chr16:29,709,743–29,710,091 | 46.7 kb | Distal (>10kb) Multiome | 21 | |
| chr16:29,784,957–29,785,426 | 122.0 kb | Distal (>10kb) Multiome | 452 | |
| chr16:29,790,073–29,791,192 | 127.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:29,804,592–29,808,172 | 142.5 kb | Distal (>10kb) Multiome | 1275 | |
| chr16:29,810,746–29,812,649 | 149.1 kb | Distal (>10kb) Multiome | 826 | |
| chr16:29,815,828–29,817,186 | 152.9 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:29,862,597–29,863,901 | 200.2 kb | Distal (>10kb) Multiome | 953 | |
| chr16:29,876,281–29,878,282 | 214.4 kb | Distal (>10kb) Multiome | 319 | |
| chr16:29,899,174–29,900,833 | 236.2 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 263.0 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 298.7 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 310.4 kb | Distal (>10kb) Multiome | 935 |
Genomic view of the QPRT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.