This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for QPCT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QPCT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QPCT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:37,083,780–37,086,187 | 258.9 kb | Distal (>10kb) Multiome | 938 | |
| chr2:37,156,055–37,157,536 | 187.8 kb | Distal (>10kb) Multiome | 702 | |
| chr2:37,231,272–37,232,043 | 113.1 kb | Distal (>10kb) Multiome | 891 | |
| chr2:37,305,706–37,306,783 | 38.6 kb | Distal (>10kb) Multiome | 129 | |
| chr2:37,323,791–37,325,583 | 19.9 kb | Distal (>10kb) Multiome | 835 | |
| chr2:37,342,701–37,343,072 | 1.7 kb | Proximal (<10kb) | 64 | |
| chr2:37,343,562–37,343,747 | 979 bp | At TSS | 106 | |
| chr2:37,344,501–37,345,213 | at TSS | At TSS | 401 | |
| chr2:37,443,019–37,443,805 | 98.7 kb | Distal (>10kb) Multiome | 55 | |
| chr2:37,535,945–37,536,470 | 191.5 kb | Distal (>10kb) Multiome | 211 |
Genomic view of the QPCT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.