The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for QKI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QKI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QKI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:163,259,825–163,261,659 | 154.1 kb | Distal (>10kb) Multiome | 268 | |
| chr6:163,264,147–163,265,383 | 150.0 kb | Distal (>10kb) Multiome | 186 | |
| chr6:163,396,440–163,397,209 | 17.7 kb | Distal (>10kb) Multiome | 158 | |
| chr6:163,413,096–163,416,202 | 70 bp | At TSS Multiome | 987 | |
| chr6:163,416,835–163,417,230 | 2.2 kb | Proximal (<10kb) | 282 | |
| chr6:163,460,258–163,460,757 | 4.9 kb | Proximal (<10kb) | 101 |
Genomic view of the QKI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.