Predicted to enable oxidoreductase activity. Involved in mitochondrion organization. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PYROXD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PYROXD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PYROXD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:98,134,300–98,135,354 | 280.5 kb | Distal (>10kb) Multiome | 772 | |
| chr10:98,309,066–98,309,892 | 105.5 kb | Distal (>10kb) Multiome | 380 | |
| chr10:98,414,616–98,415,730 | 41 bp | At TSS Multiome | 701 | |
| chr10:98,423,720–98,423,998 | 8.5 kb | Proximal (<10kb) | 176 | |
| chr10:98,446,188–98,447,219 | 31.7 kb | Distal (>10kb) Multiome | 725 | |
| chr10:98,467,326–98,468,343 | 52.5 kb | Distal (>10kb) Multiome | 539 | |
| chr10:98,559,915–98,560,656 | 145.1 kb | Distal (>10kb) Multiome | 57 | |
| chr10:98,601,370–98,602,074 | 186.5 kb | Distal (>10kb) Multiome | 96 | |
| chr10:98,620,457–98,621,138 | 205.5 kb | Distal (>10kb) Multiome | 169 | |
| chr10:99,266,221–99,266,995 | 851.4 kb | Distal (>10kb) Multiome HiCAR | 113 | |
| chr10:99,370,159–99,370,697 | 955.2 kb | Distal (>10kb) Multiome HiCAR | 14 |
Genomic view of the PYROXD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.