Enables phosphatase activity. Involved in chondroitin sulfate proteoglycan biosynthetic process and positive regulation of heparan sulfate proteoglycan biosynthetic process. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PXYLP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PXYLP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PXYLP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:140,941,304–140,943,041 | 289.0 kb | Distal (>10kb) Multiome | 1087 | |
| chr3:141,050,639–141,052,361 | 180.5 kb | Distal (>10kb) Multiome | 469 | |
| chr3:141,070,840–141,071,438 | 160.7 kb | Distal (>10kb) Multiome | 164 | |
| chr3:141,074,501–141,074,972 | 157.2 kb | Distal (>10kb) Multiome | 69 | |
| chr3:141,231,050–141,232,888 | 113 bp | At TSS Multiome | 693 | |
| chr3:141,311,338–141,312,269 | 80.0 kb | Distal (>10kb) Multiome | 905 | |
| chr3:141,393,230–141,393,880 | 161.6 kb | Distal (>10kb) Multiome | 267 | |
| chr3:141,401,959–141,403,068 | 170.7 kb | Distal (>10kb) Multiome | 621 | |
| chr3:141,486,398–141,488,045 | 255.2 kb | Distal (>10kb) Multiome | 864 |
Genomic view of the PXYLP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.