The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for PWP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PWP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PWP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:107,580,999–107,581,602 | 104.5 kb | Distal (>10kb) Multiome | 125 | |
| chr12:107,609,968–107,610,492 | 75.6 kb | Distal (>10kb) Multiome | 91 | |
| chr12:107,634,992–107,635,543 | 50.5 kb | Distal (>10kb) Multiome | 94 | |
| chr12:107,645,427–107,646,365 | 39.8 kb | Distal (>10kb) Multiome | 246 | |
| chr12:107,685,091–107,685,330 | 467 bp | At TSS | 306 | |
| chr12:107,685,428–107,686,240 | 55 bp | At TSS Multiome | 930 | |
| chr12:107,760,460–107,761,864 | 75.4 kb | Distal (>10kb) Multiome | 768 | |
| chr12:107,775,288–107,775,778 | 89.7 kb | Distal (>10kb) Multiome | 233 | |
| chr12:107,843,356–107,844,974 | 158.7 kb | Distal (>10kb) Multiome | 255 | |
| chr12:107,864,203–107,864,687 | 178.8 kb | Distal (>10kb) Multiome | 117 | |
| chr12:107,898,054–107,898,586 | 212.6 kb | Distal (>10kb) Multiome HiCAR | 13 | |
| chr12:107,903,668–107,904,167 | 218.0 kb | Distal (>10kb) Multiome HiCAR | 469 | |
| chr12:107,912,390–107,913,032 | 226.9 kb | Distal (>10kb) Multiome HiCAR | 361 | |
| chr12:108,514,776–108,515,777 | 829.4 kb | Distal (>10kb) Multiome HiCAR | 685 |
Genomic view of the PWP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.