This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for PTPRZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPRZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPRZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:121,798,919–121,799,535 | 74.0 kb | Distal (>10kb) Multiome | 154 | |
| chr7:121,872,464–121,874,098 | 29 bp | At TSS Multiome | 428 | |
| chr7:121,882,380–121,882,573 | 9.2 kb | Proximal (<10kb) | 3 | |
| chr7:121,936,364–121,937,841 | 63.7 kb | Distal (>10kb) Multiome | 148 | |
| chr7:121,938,241–121,939,440 | 65.5 kb | Distal (>10kb) Multiome | 264 | |
| chr7:122,143,073–122,145,002 | 271.1 kb | Distal (>10kb) Multiome | 722 |
Genomic view of the PTPRZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.