The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PTPN21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPN21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPN21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:88,322,020–88,324,446 | 231.4 kb | Distal (>10kb) Multiome | 373 | |
| chr14:88,364,579–88,365,430 | 190.0 kb | Distal (>10kb) Multiome | 118 | |
| chr14:88,385,143–88,386,368 | 169.3 kb | Distal (>10kb) Multiome | 743 | |
| chr14:88,551,095–88,552,499 | 3.4 kb | Proximal (<10kb) Multiome | 512 | |
| chr14:88,554,467–88,555,337 | 130 bp | At TSS Multiome | 594 | |
| chr14:88,562,461–88,563,844 | 8.2 kb | Proximal (<10kb) Multiome | 904 | |
| chr14:88,682,305–88,683,364 | 127.7 kb | Distal (>10kb) Multiome | 210 | |
| chr14:88,791,992–88,793,502 | 237.9 kb | Distal (>10kb) Multiome | 611 | |
| chr14:88,824,077–88,825,117 | 269.6 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the PTPN21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.