PTPMT1
protein tyrosine phosphatase mitochondrial 1 | DUSP23, MOSP, PLIP

Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of intrinsic apoptotic signaling pathway. Located in nucleus. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1
Biological processes 23 terms
cardiolipin biosynthetic process (GO:0032049)cardiolipin biosynthetic process (GO:0032049)cardiolipin biosynthetic process (GO:0032049)cardiolipin biosynthetic process (GO:0032049)mitochondrial fragmentation involved in apoptotic process (GO:0043653)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)nucleus (GO:0005634)phosphatidylglycerol biosynthetic process (GO:0006655)phosphatidylglycerophosphatase activity (GO:0008962)phosphatidylglycerophosphatase activity (GO:0008962)phosphatidylglycerophosphatase activity (GO:0008962)phosphatidylinositol-5-phosphate phosphatase activity (GO:0102091)phosphatidylinositol-5-phosphate phosphatase activity (GO:0102091)phosphoprotein phosphatase activity (GO:0004721)protein binding (GO:0005515)protein serine/threonine phosphatase activity (GO:0004722)protein tyrosine phosphatase activity (GO:0004725)regulation of intrinsic apoptotic signaling pathway (GO:2001242)
Expression (TPM)
PTPMT1 — as a Regulated Gene

TFs regulating PTPMT1 0 TFs

Transcription factors with Perturb-seq knockdown data for PTPMT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPMT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PTPMT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPMT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:47,268,988–47,270,613 295.8 kb Distal (>10kb) Multiome 884
chr11:47,354,896–47,355,720 210.2 kb Distal (>10kb) Multiome 670
chr11:47,399,791–47,400,763 165.3 kb Distal (>10kb) Multiome 450
chr11:47,407,671–47,409,059 157.2 kb Distal (>10kb) Multiome 986
chr11:47,425,998–47,427,263 139.1 kb Distal (>10kb) Multiome 879
chr11:47,508,005–47,509,036 57.1 kb Distal (>10kb) Multiome 73
chr11:47,552,255–47,553,700 12.3 kb Distal (>10kb) Multiome 834
chr11:47,564,988–47,566,330 12 bp At TSS Multiome 842
chr11:47,578,427–47,579,510 13.3 kb Distal (>10kb) Multiome 1080
chr11:47,589,692–47,590,847 24.7 kb Distal (>10kb) Multiome 161
chr11:47,594,122–47,594,733 28.7 kb Distal (>10kb) Multiome 153
chr11:47,598,993–47,599,885 33.8 kb Distal (>10kb) Multiome 67
chr11:47,642,000–47,643,006 77.0 kb Distal (>10kb) Multiome 973
chr11:47,714,892–47,715,563 149.7 kb Distal (>10kb) Multiome 607
chr11:47,766,463–47,768,105 201.9 kb Distal (>10kb) Multiome 961
chr11:47,847,845–47,848,997 282.8 kb Distal (>10kb) Multiome 863

Genome Browser

Genomic view of the PTPMT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:47,258,988 – 47,858,997
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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