The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PTPDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:93,826,327–93,826,940 | 204.4 kb | Distal (>10kb) Multiome | 168 | |
| chr9:93,827,082–93,828,691 | 203.1 kb | Distal (>10kb) Multiome | 373 | |
| chr9:93,948,645–93,949,108 | 81.8 kb | Distal (>10kb) Multiome | 65 | |
| chr9:93,954,201–93,955,998 | 75.3 kb | Distal (>10kb) Multiome | 228 | |
| chr9:94,030,363–94,031,139 | 4 bp | At TSS Multiome | 869 | |
| chr9:94,165,559–94,167,324 | 136.1 kb | Distal (>10kb) Multiome | 1085 | |
| chr9:94,250,394–94,250,997 | 220.0 kb | Distal (>10kb) Multiome | 81 | |
| chr9:94,259,139–94,259,781 | 228.5 kb | Distal (>10kb) Multiome | 663 |
Genomic view of the PTPDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.