This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PTK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:42,782,323–42,783,894 | 293.4 kb | Distal (>10kb) Multiome | 960 | |
| chr6:42,879,371–42,880,327 | 196.5 kb | Distal (>10kb) Multiome | 982 | |
| chr6:42,890,329–42,891,383 | 185.5 kb | Distal (>10kb) Multiome | 1066 | |
| chr6:42,911,181–42,912,079 | 164.6 kb | Distal (>10kb) Multiome | 327 | |
| chr6:42,928,809–42,930,153 | 146.9 kb | Distal (>10kb) Multiome | 1111 | |
| chr6:42,960,347–42,961,147 | 115.6 kb | Distal (>10kb) Multiome | 597 | |
| chr6:42,978,475–42,979,742 | 97.1 kb | Distal (>10kb) Multiome | 914 | |
| chr6:42,983,832–42,985,046 | 91.9 kb | Distal (>10kb) Multiome | 737 | |
| chr6:43,013,264–43,014,790 | 62.2 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,020,970–43,021,878 | 54.8 kb | Distal (>10kb) Multiome | 766 | |
| chr6:43,053,156–43,054,116 | 22.5 kb | Distal (>10kb) Multiome | 1033 | |
| chr6:43,059,118–43,060,383 | 16.7 kb | Distal (>10kb) Multiome | 906 | |
| chr6:43,075,612–43,077,611 | 1.1 kb | Proximal (<10kb) Multiome | 744 | |
| chr6:43,096,382–43,096,822 | 20.1 kb | Distal (>10kb) Multiome | 290 | |
| chr6:43,143,296–43,143,802 | 67.3 kb | Distal (>10kb) Multiome HiCAR | 638 | |
| chr6:43,170,289–43,172,815 | 94.9 kb | Distal (>10kb) Multiome | 1025 | |
| chr6:43,173,720–43,174,910 | 98.2 kb | Distal (>10kb) Multiome | 765 | |
| chr6:43,181,838–43,182,555 | 105.8 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,228,982–43,229,794 | 153.1 kb | Distal (>10kb) Multiome | 918 | |
| chr6:43,246,576–43,247,616 | 170.9 kb | Distal (>10kb) Multiome | 750 | |
| chr6:43,267,244–43,268,167 | 191.3 kb | Distal (>10kb) Multiome | 772 | |
| chr6:43,285,054–43,285,508 | 209.0 kb | Distal (>10kb) Multiome | 68 | |
| chr6:43,308,219–43,309,149 | 232.5 kb | Distal (>10kb) Multiome | 462 | |
| chr6:43,368,714–43,370,143 | 293.3 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the PTK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.