This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for PTGR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTGR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTGR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:73,569,145–73,570,199 | 282.6 kb | Distal (>10kb) Multiome | 680 | |
| chr14:73,591,810–73,592,493 | 259.8 kb | Distal (>10kb) Multiome | 259 | |
| chr14:73,612,266–73,613,237 | 239.3 kb | Distal (>10kb) Multiome | 521 | |
| chr14:73,633,521–73,634,788 | 218.3 kb | Distal (>10kb) Multiome | 541 | |
| chr14:73,644,535–73,645,291 | 207.0 kb | Distal (>10kb) Multiome | 667 | |
| chr14:73,713,545–73,714,769 | 137.6 kb | Distal (>10kb) Multiome | 759 | |
| chr14:73,718,770–73,719,334 | 132.8 kb | Distal (>10kb) Multiome | 138 | |
| chr14:73,759,247–73,760,633 | 91.6 kb | Distal (>10kb) Multiome | 912 | |
| chr14:73,771,644–73,772,269 | 79.9 kb | Distal (>10kb) Multiome | 846 | |
| chr14:73,785,281–73,785,818 | 66.4 kb | Distal (>10kb) Multiome | 458 | |
| chr14:73,786,685–73,787,517 | 64.7 kb | Distal (>10kb) Multiome | 497 | |
| chr14:73,851,491–73,852,843 | 53 bp | At TSS Multiome | 842 | |
| chr14:73,886,331–73,887,426 | 34.9 kb | Distal (>10kb) Multiome | 963 | |
| chr14:73,949,767–73,950,750 | 98.3 kb | Distal (>10kb) Multiome | 932 | |
| chr14:74,018,639–74,019,694 | 167.4 kb | Distal (>10kb) Multiome | 791 | |
| chr14:74,083,828–74,085,467 | 232.7 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the PTGR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.