Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PSMG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:38,945,569–38,946,100 | 237.6 kb | Distal (>10kb) Multiome | 116 | |
| chr21:38,979,289–38,980,192 | 203.8 kb | Distal (>10kb) Multiome | 172 | |
| chr21:38,995,212–38,995,827 | 187.9 kb | Distal (>10kb) Multiome | 25 | |
| chr21:39,173,869–39,174,375 | 9.1 kb | Proximal (<10kb) | 48 | |
| chr21:39,182,840–39,184,214 | 199 bp | At TSS Multiome | 1028 | |
| chr21:39,312,364–39,314,680 | 130.4 kb | Distal (>10kb) Multiome | 1121 | |
| chr21:39,332,179–39,332,739 | 149.0 kb | Distal (>10kb) Multiome | 188 | |
| chr21:39,348,209–39,350,114 | 165.8 kb | Distal (>10kb) Multiome | 923 | |
| chr21:39,380,111–39,380,888 | 196.9 kb | Distal (>10kb) Multiome | 663 | |
| chr21:39,387,404–39,389,039 | 205.4 kb | Distal (>10kb) Multiome | 713 | |
| chr21:39,429,900–39,431,278 | 247.2 kb | Distal (>10kb) Multiome | 277 | |
| chr21:39,445,343–39,446,179 | 262.4 kb | Distal (>10kb) Multiome | 837 | |
| chr21:39,451,559–39,452,036 | 268.3 kb | Distal (>10kb) Multiome | 267 |
Genomic view of the PSMG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.