Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and sperm DNA condensation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PSME4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSME4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSME4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:53,767,422–53,768,367 | 202.9 kb | Distal (>10kb) Multiome | 710 | |
| chr2:53,786,365–53,787,886 | 183.8 kb | Distal (>10kb) Multiome | 999 | |
| chr2:53,859,343–53,860,396 | 110.9 kb | Distal (>10kb) Multiome | 238 | |
| chr2:53,970,071–53,971,956 | 373 bp | At TSS Multiome | 992 | |
| chr2:53,973,080–53,973,900 | 2.8 kb | Proximal (<10kb) Multiome | 37 | |
| chr2:54,087,898–54,089,384 | 117.6 kb | Distal (>10kb) Multiome | 214 | |
| chr2:54,115,347–54,116,192 | 145.0 kb | Distal (>10kb) Multiome | 1060 |
Genomic view of the PSME4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.