This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for PSMD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:63,725,749–63,726,278 | 297.5 kb | Distal (>10kb) Multiome | 193 | |
| chr3:63,847,826–63,848,634 | 175.3 kb | Distal (>10kb) Multiome | 147 | |
| chr3:63,863,192–63,864,606 | 159.6 kb | Distal (>10kb) Multiome | 635 | |
| chr3:63,911,642–63,913,487 | 111.4 kb | Distal (>10kb) Multiome | 823 | |
| chr3:64,023,033–64,023,678 | 4 bp | At TSS Multiome | 925 | |
| chr3:64,030,557–64,031,016 | 7.4 kb | Proximal (<10kb) Multiome | 509 | |
| chr3:64,063,306–64,064,385 | 40.4 kb | Distal (>10kb) Multiome | 142 | |
| chr3:64,267,687–64,268,494 | 244.6 kb | Distal (>10kb) Multiome | 241 | |
| chr3:64,444,744–64,445,851 | 422.0 kb | Distal (>10kb) Multiome HiCAR | 328 | |
| chr3:64,489,031–64,490,029 | 466.1 kb | Distal (>10kb) Multiome HiCAR | 232 |
Genomic view of the PSMD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.