The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PSMB6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMB6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMB6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:4,498,488–4,499,859 | 297.3 kb | Distal (>10kb) Multiome | 361 | |
| chr17:4,555,276–4,555,773 | 240.7 kb | Distal (>10kb) Multiome | 806 | |
| chr17:4,583,931–4,585,086 | 211.8 kb | Distal (>10kb) Multiome | 323 | |
| chr17:4,703,669–4,704,637 | 92.0 kb | Distal (>10kb) Multiome | 854 | |
| chr17:4,708,553–4,709,232 | 87.4 kb | Distal (>10kb) Multiome | 71 | |
| chr17:4,709,724–4,711,094 | 85.7 kb | Distal (>10kb) Multiome | 771 | |
| chr17:4,730,794–4,732,115 | 64.6 kb | Distal (>10kb) Multiome | 936 | |
| chr17:4,745,124–4,745,511 | 50.7 kb | Distal (>10kb) Multiome | 67 | |
| chr17:4,788,894–4,789,492 | 6.7 kb | Proximal (<10kb) | 458 | |
| chr17:4,789,618–4,790,520 | 5.9 kb | Proximal (<10kb) Multiome | 816 | |
| chr17:4,795,974–4,796,433 | 4 bp | At TSS Multiome | 751 | |
| chr17:4,806,693–4,807,619 | 10.9 kb | Distal (>10kb) Multiome | 494 | |
| chr17:4,832,863–4,833,956 | 37.2 kb | Distal (>10kb) Multiome | 730 | |
| chr17:4,898,962–4,900,112 | 103.3 kb | Distal (>10kb) Multiome | 257 | |
| chr17:4,900,249–4,901,057 | 104.6 kb | Distal (>10kb) Multiome | 145 | |
| chr17:4,909,117–4,909,538 | 113.1 kb | Distal (>10kb) Multiome | 553 | |
| chr17:4,939,475–4,941,034 | 144.0 kb | Distal (>10kb) Multiome | 821 | |
| chr17:4,947,426–4,950,636 | 154.0 kb | Distal (>10kb) Multiome | 1080 | |
| chr17:4,966,739–4,968,875 | 171.4 kb | Distal (>10kb) Multiome | 982 | |
| chr17:4,986,950–4,987,983 | 191.4 kb | Distal (>10kb) Multiome | 881 | |
| chr17:4,996,838–4,998,964 | 201.6 kb | Distal (>10kb) Multiome | 759 | |
| chr17:5,031,487–5,032,081 | 235.5 kb | Distal (>10kb) Multiome | 342 |
Genomic view of the PSMB6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.