The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for PSMB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:35,390,099–35,390,702 | 251.1 kb | Distal (>10kb) Multiome | 47 | |
| chr1:35,390,839–35,391,860 | 250.3 kb | Distal (>10kb) Multiome | 219 | |
| chr1:35,533,667–35,534,085 | 107.6 kb | Distal (>10kb) Multiome | 64 | |
| chr1:35,556,848–35,558,023 | 83.9 kb | Distal (>10kb) Multiome | 894 | |
| chr1:35,573,081–35,573,635 | 68.1 kb | Distal (>10kb) Multiome | 174 | |
| chr1:35,577,045–35,577,930 | 63.9 kb | Distal (>10kb) Multiome | 235 | |
| chr1:35,641,114–35,641,872 | 69 bp | At TSS Multiome | 824 | |
| chr1:35,707,208–35,708,693 | 66.4 kb | Distal (>10kb) Multiome | 388 | |
| chr1:35,717,979–35,719,281 | 77.4 kb | Distal (>10kb) Multiome | 558 | |
| chr1:35,769,208–35,770,406 | 128.5 kb | Distal (>10kb) Multiome | 929 | |
| chr1:35,807,537–35,808,824 | 166.5 kb | Distal (>10kb) Multiome | 575 | |
| chr1:35,882,591–35,884,430 | 241.6 kb | Distal (>10kb) Multiome | 802 | |
| chr1:35,885,650–35,886,507 | 244.6 kb | Distal (>10kb) Multiome | 156 | |
| chr1:35,930,610–35,931,886 | 289.5 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the PSMB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.