The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PSMA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:42,887,741–42,889,424 | 43.8 kb | Distal (>10kb) Multiome | 819 | |
| chr7:42,911,366–42,912,538 | 20.2 kb | Distal (>10kb) Multiome | 975 | |
| chr7:42,931,754–42,932,671 | 103 bp | At TSS Multiome | 701 | |
| chr7:42,932,877–42,933,530 | 692 bp | At TSS | 165 | |
| chr7:42,941,099–42,941,745 | 8.9 kb | Proximal (<10kb) | 272 | |
| chr7:42,965,185–42,965,768 | 33.2 kb | Distal (>10kb) Multiome | 88 | |
| chr7:43,108,219–43,108,698 | 176.3 kb | Distal (>10kb) Multiome | 184 | |
| chr7:43,112,283–43,114,054 | 181.0 kb | Distal (>10kb) Multiome HiCAR | 392 | |
| chr7:43,439,357–43,440,269 | 507.6 kb | Distal (>10kb) Multiome HiCAR | 289 |
Genomic view of the PSMA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.