Enables antioxidant activity. Involved in regulation of osteoclast differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRXL2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRXL2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRXL2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:80,132,279–80,133,011 | 275.9 kb | Distal (>10kb) Multiome | 155 | |
| chr10:80,204,736–80,206,157 | 203.0 kb | Distal (>10kb) Multiome | 830 | |
| chr10:80,207,076–80,207,999 | 201.0 kb | Distal (>10kb) Multiome | 466 | |
| chr10:80,265,707–80,266,498 | 142.5 kb | Distal (>10kb) Multiome | 166 | |
| chr10:80,356,265–80,357,947 | 51.6 kb | Distal (>10kb) Multiome | 316 | |
| chr10:80,405,742–80,405,952 | 2.6 kb | Proximal (<10kb) | 50 | |
| chr10:80,407,698–80,409,441 | 45 bp | At TSS Multiome | 766 | |
| chr10:80,413,694–80,414,385 | 5.1 kb | Proximal (<10kb) | 261 | |
| chr10:80,417,201–80,417,834 | 8.7 kb | Proximal (<10kb) | 62 | |
| chr10:80,453,293–80,455,470 | 45.6 kb | Distal (>10kb) Multiome | 715 | |
| chr10:80,460,762–80,461,239 | 52.4 kb | Distal (>10kb) Multiome | 249 | |
| chr10:80,464,428–80,465,474 | 56.3 kb | Distal (>10kb) Multiome | 372 | |
| chr10:80,537,302–80,538,301 | 129.3 kb | Distal (>10kb) Multiome | 133 | |
| chr10:80,662,717–80,663,273 | 254.3 kb | Distal (>10kb) Multiome | 337 | |
| chr10:80,699,208–80,700,299 | 291.2 kb | Distal (>10kb) Multiome | 353 | |
| chr10:81,874,006–81,877,324 | 1466.3 kb | Distal (>10kb) Multiome HiCAR | 461 |
Genomic view of the PRXL2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.