This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for PRTG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRTG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRTG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:55,498,088–55,498,593 | 244.7 kb | Distal (>10kb) Multiome | 637 | |
| chr15:55,587,537–55,588,889 | 154.8 kb | Distal (>10kb) Multiome | 432 | |
| chr15:55,688,707–55,689,258 | 54.1 kb | Distal (>10kb) Multiome | 82 | |
| chr15:55,738,358–55,738,564 | 4.6 kb | Proximal (<10kb) | 58 | |
| chr15:55,738,675–55,738,932 | 4.2 kb | Proximal (<10kb) | 55 | |
| chr15:55,741,161–55,743,756 | 103 bp | At TSS Multiome | 809 | |
| chr15:55,992,927–55,994,423 | 250.4 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the PRTG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.