Enables identical protein binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRPSAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRPSAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRPSAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:76,072,173–76,072,853 | 281.3 kb | Distal (>10kb) Multiome | 893 | |
| chr17:76,074,414–76,075,796 | 279.3 kb | Distal (>10kb) Multiome | 280 | |
| chr17:76,103,272–76,104,343 | 250.1 kb | Distal (>10kb) Multiome | 798 | |
| chr17:76,121,142–76,122,265 | 232.3 kb | Distal (>10kb) Multiome | 689 | |
| chr17:76,132,004–76,133,216 | 221.2 kb | Distal (>10kb) Multiome | 536 | |
| chr17:76,135,151–76,135,652 | 218.7 kb | Distal (>10kb) Multiome | 104 | |
| chr17:76,141,012–76,141,958 | 212.5 kb | Distal (>10kb) Multiome | 616 | |
| chr17:76,240,278–76,241,169 | 113.2 kb | Distal (>10kb) Multiome | 560 | |
| chr17:76,264,834–76,266,286 | 88.8 kb | Distal (>10kb) Multiome | 868 | |
| chr17:76,353,245–76,354,535 | 111 bp | At TSS Multiome | 1071 | |
| chr17:76,383,686–76,385,081 | 30.6 kb | Distal (>10kb) Multiome | 823 | |
| chr17:76,385,493–76,386,382 | 32.1 kb | Distal (>10kb) Multiome | 935 | |
| chr17:76,452,469–76,453,735 | 99.3 kb | Distal (>10kb) Multiome | 726 | |
| chr17:76,500,907–76,502,333 | 147.5 kb | Distal (>10kb) Multiome | 728 | |
| chr17:76,506,248–76,506,840 | 152.6 kb | Distal (>10kb) Multiome | 550 | |
| chr17:76,537,326–76,538,627 | 183.9 kb | Distal (>10kb) Multiome | 192 | |
| chr17:76,540,451–76,541,323 | 187.1 kb | Distal (>10kb) Multiome | 478 | |
| chr17:76,557,376–76,557,942 | 203.8 kb | Distal (>10kb) Multiome | 906 | |
| chr17:76,585,404–76,586,417 | 232.0 kb | Distal (>10kb) Multiome | 591 | |
| chr17:76,612,985–76,613,550 | 259.4 kb | Distal (>10kb) Multiome | 308 |
Genomic view of the PRPSAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.