Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PROSER3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PROSER3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PROSER3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,471,034–35,471,539 | 286.9 kb | Distal (>10kb) Multiome | 15 | |
| chr19:35,509,786–35,510,900 | 247.7 kb | Distal (>10kb) Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 212.6 kb | Distal (>10kb) Multiome | 879 | |
| chr19:35,557,343–35,558,684 | 200.1 kb | Distal (>10kb) Multiome | 452 | |
| chr19:35,612,546–35,613,176 | 145.5 kb | Distal (>10kb) Multiome | 778 | |
| chr19:35,628,465–35,629,474 | 129.3 kb | Distal (>10kb) Multiome | 889 | |
| chr19:35,641,602–35,642,192 | 116.4 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,643,064–35,645,730 | 114.6 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:35,648,040–35,648,575 | 110.0 kb | Distal (>10kb) Multiome | 599 | |
| chr19:35,673,179–35,673,643 | 84.8 kb | Distal (>10kb) Multiome | 311 | |
| chr19:35,702,152–35,702,985 | 55.7 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 40.5 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 17.4 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 12.9 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 9.7 kb | Proximal (<10kb) Multiome | 749 | |
| chr19:35,755,662–35,756,025 | 2.2 kb | Proximal (<10kb) | 111 | |
| chr19:35,756,416–35,757,116 | 1.1 kb | Proximal (<10kb) | 159 | |
| chr19:35,757,432–35,758,657 | 94 bp | At TSS Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 9.8 kb | Proximal (<10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 17.3 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 26.5 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,860,621–35,861,651 | 103.1 kb | Distal (>10kb) Multiome | 299 | |
| chr19:35,868,369–35,868,860 | 110.3 kb | Distal (>10kb) Multiome | 320 | |
| chr19:35,869,343–35,870,482 | 111.7 kb | Distal (>10kb) Multiome | 492 | |
| chr19:35,899,240–35,900,760 | 141.5 kb | Distal (>10kb) Multiome | 751 | |
| chr19:35,931,342–35,932,167 | 173.5 kb | Distal (>10kb) Multiome | 835 | |
| chr19:35,936,083–35,936,704 | 178.2 kb | Distal (>10kb) Multiome | 417 | |
| chr19:35,986,945–35,987,622 | 229.1 kb | Distal (>10kb) Multiome | 363 | |
| chr19:35,994,796–35,995,940 | 237.0 kb | Distal (>10kb) Multiome | 897 | |
| chr19:36,008,519–36,009,006 | 250.6 kb | Distal (>10kb) Multiome | 427 | |
| chr19:36,013,972–36,014,810 | 256.2 kb | Distal (>10kb) Multiome | 623 | |
| chr19:36,032,424–36,033,187 | 274.7 kb | Distal (>10kb) Multiome | 179 | |
| chr19:36,053,782–36,055,591 | 296.3 kb | Distal (>10kb) Multiome | 1026 |
Genomic view of the PROSER3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.