Transcription factors with Perturb-seq knockdown data for PROSER2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PROSER2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PROSER2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:11,610,860–11,612,125 | 211.7 kb | Distal (>10kb) Multiome | 748 | |
| chr10:11,741,667–11,743,276 | 81.0 kb | Distal (>10kb) Multiome | 482 | |
| chr10:11,799,285–11,799,933 | 23.8 kb | Distal (>10kb) Multiome | 102 | |
| chr10:11,823,198–11,824,010 | 81 bp | At TSS Multiome | 551 | |
| chr10:11,830,789–11,831,374 | 7.4 kb | Proximal (<10kb) | 231 | |
| chr10:11,869,855–11,870,414 | 46.9 kb | Distal (>10kb) Multiome | 105 | |
| chr10:11,874,348–11,875,590 | 51.5 kb | Distal (>10kb) Multiome | 672 | |
| chr10:11,913,209–11,913,675 | 90.1 kb | Distal (>10kb) Multiome | 34 | |
| chr10:12,041,862–12,043,685 | 219.8 kb | Distal (>10kb) Multiome | 849 | |
| chr10:12,063,340–12,063,818 | 240.2 kb | Distal (>10kb) Multiome | 219 | |
| chr10:12,068,387–12,069,409 | 245.5 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the PROSER2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.