The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for PRKAR1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRKAR1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRKAR1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:321,971–322,829 | 405.3 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr7:332,380–333,313 | 394.8 kb | Distal (>10kb) Multiome HiCAR | 649 | |
| chr7:515,390–516,162 | 211.8 kb | Distal (>10kb) Multiome | 84 | |
| chr7:518,879–521,101 | 207.5 kb | Distal (>10kb) Multiome | 523 | |
| chr7:726,194–727,335 | 944 bp | At TSS Multiome | 891 | |
| chr7:815,511–817,550 | 88.7 kb | Distal (>10kb) Multiome | 640 | |
| chr7:875,946–877,507 | 148.9 kb | Distal (>10kb) Multiome | 918 | |
| chr7:901,112–902,113 | 174.0 kb | Distal (>10kb) Multiome | 376 | |
| chr7:953,606–955,017 | 226.9 kb | Distal (>10kb) Multiome | 482 | |
| chr7:974,909–975,889 | 247.9 kb | Distal (>10kb) Multiome | 860 | |
| chr7:992,812–993,637 | 265.6 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the PRKAR1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.