The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for PRIMA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRIMA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRIMA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:93,669,677–93,670,358 | 118.5 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr14:93,687,932–93,689,042 | 100.0 kb | Distal (>10kb) Multiome | 186 | |
| chr14:93,787,427–93,789,655 | 190 bp | At TSS Multiome | 458 | |
| chr14:93,791,033–93,791,240 | 2.5 kb | Proximal (<10kb) | 8 | |
| chr14:93,938,972–93,940,225 | 151.2 kb | Distal (>10kb) Multiome HiCAR | 431 | |
| chr14:94,026,129–94,026,981 | 237.9 kb | Distal (>10kb) Multiome | 519 | |
| chr14:94,036,395–94,037,000 | 248.2 kb | Distal (>10kb) Multiome | 225 | |
| chr14:94,080,803–94,081,695 | 292.8 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the PRIMA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.