PRDX2

peroxiredoxin 2 | MGC4104, NKEFB, PRP, PRX2, PRXII, TSA, TDPX1

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

Member of: DE-1 DE-1.24 Developmental clusters: GC6

Biological processes 31 terms

antioxidant activity (GO:0016209)antioxidant activity (GO:0016209)antioxidant activity (GO:0016209)cell redox homeostasis (GO:0045454)cellular response to oxidative stress (GO:0034599)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)defense response to tumor cell (GO:0002357)extracellular exosome (GO:0070062)hydrogen peroxide catabolic process (GO:0042744)hydrogen peroxide catabolic process (GO:0042744)leukocyte activation (GO:0045321)negative regulation of apoptotic process (GO:0043066)oxidoreductase activity (GO:0016491)peroxiredoxin activity (GO:0051920)positive regulation of blood coagulation (GO:0030194)protein binding (GO:0005515)regulation of apoptotic process (GO:0042981)removal of superoxide radicals (GO:0019430)removal of superoxide radicals (GO:0019430)removal of superoxide radicals (GO:0019430)response to oxidative stress (GO:0006979)response to oxidative stress (GO:0006979)response to oxidative stress (GO:0006979)thioredoxin peroxidase activity (GO:0008379)thioredoxin peroxidase activity (GO:0008379)thioredoxin peroxidase activity (GO:0008379)thioredoxin-dependent peroxiredoxin activity (GO:0140824)

Expression (TPM)

TFs regulating PRDX2 0 TFs

Transcription factors with Perturb-seq knockdown data for PRDX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PRDX2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,550,951–12,551,971	250.3 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	230.1 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	190.9 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	161.6 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	154.1 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	144.6 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	135.0 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	132.2 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	120.4 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	105.2 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	98.6 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	79.3 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	77.7 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	67.1 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	64.7 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	44.0 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	35.5 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	26.4 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	23.9 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	19.1 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	11.8 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	10.3 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	8.1 kb	Proximal (<10kb) Multiome	808
chr19:12,796,584–12,797,024	4.8 kb	Proximal (<10kb)	479
chr19:12,801,120–12,802,290	128 bp	At TSS Multiome	901
chr19:12,806,212–12,806,984	4.8 kb	Proximal (<10kb) Multiome	827
chr19:12,825,565–12,826,186	24.0 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	30.8 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	32.1 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	36.7 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	39.1 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	46.0 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	65.8 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	71.6 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	79.7 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	83.6 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	89.2 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	111.5 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	117.6 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	132.0 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	136.6 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	144.1 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	155.4 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	163.6 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	181.9 kb	Distal (>10kb) Multiome	688
chr19:13,051,485–13,052,169	250.0 kb	Distal (>10kb) Multiome	649
chr19:13,061,195–13,061,672	259.7 kb	Distal (>10kb) Multiome	544
chr19:13,069,469–13,070,306	268.0 kb	Distal (>10kb) Multiome	334
chr19:13,093,620–13,094,260	292.1 kb	Distal (>10kb) Multiome	411
chr19:13,095,079–13,096,870	293.7 kb	Distal (>10kb) Multiome	501

Genome Browser

Genomic view of the PRDX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.