Enables protein serine/threonine phosphatase activity and protein-macromolecule adaptor activity. Involved in negative regulation of mitophagy and positive regulation of ubiquinone biosynthetic process. Located in mitochondrial matrix. Is active in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPTC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPTC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPTC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:110,403,190–110,403,822 | 179.6 kb | Distal (>10kb) Multiome | 779 | |
| chr12:110,431,453–110,431,925 | 151.7 kb | Distal (>10kb) Multiome | 461 | |
| chr12:110,449,732–110,450,544 | 133.0 kb | Distal (>10kb) Multiome | 883 | |
| chr12:110,468,018–110,469,597 | 114.0 kb | Distal (>10kb) Multiome HiCAR | 1093 | |
| chr12:110,501,642–110,502,585 | 81.2 kb | Distal (>10kb) Multiome HiCAR | 1115 | |
| chr12:110,582,284–110,583,969 | 37 bp | At TSS Multiome | 740 | |
| chr12:110,613,705–110,614,482 | 30.7 kb | Distal (>10kb) Multiome | 791 | |
| chr12:110,688,496–110,690,180 | 106.0 kb | Distal (>10kb) Multiome | 414 | |
| chr12:110,742,238–110,743,370 | 159.7 kb | Distal (>10kb) Multiome | 801 | |
| chr12:110,772,664–110,773,461 | 189.7 kb | Distal (>10kb) Multiome | 88 | |
| chr12:110,846,588–110,847,239 | 263.6 kb | Distal (>10kb) Multiome | 371 | |
| chr12:110,860,936–110,861,527 | 277.9 kb | Distal (>10kb) Multiome | 127 |
Genomic view of the PPTC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.