Transcription factors with Perturb-seq knockdown data for PPP4R3B-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP4R3B-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP4R3B-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:55,610,662–55,611,055 | 6.8 kb | Proximal (<10kb) | 34 | |
| chr2:55,616,515–55,618,979 | at TSS | At TSS | 1070 | |
| chr2:55,620,250–55,620,479 | 2.4 kb | Proximal (<10kb) | 110 | |
| chr2:55,622,456–55,622,938 | 4.6 kb | Proximal (<10kb) | 8 | |
| chr2:55,626,227–55,626,607 | 8.4 kb | Proximal (<10kb) | 31 |
Genomic view of the PPP4R3B-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.