The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPP2R2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP2R2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP2R2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:6,198,414–6,201,258 | 273.6 kb | Distal (>10kb) Multiome | 514 | |
| chr4:6,221,494–6,222,648 | 250.6 kb | Distal (>10kb) Multiome | 327 | |
| chr4:6,245,263–6,246,104 | 226.9 kb | Distal (>10kb) Multiome | 152 | |
| chr4:6,269,131–6,270,539 | 202.9 kb | Distal (>10kb) Multiome | 561 | |
| chr4:6,308,663–6,309,660 | 163.5 kb | Distal (>10kb) Multiome | 421 | |
| chr4:6,470,551–6,471,324 | 1.3 kb | Proximal (<10kb) | 373 | |
| chr4:6,472,122–6,472,949 | 13 bp | At TSS Multiome | 157 | |
| chr4:6,574,723–6,575,464 | 102.5 kb | Distal (>10kb) Multiome | 601 | |
| chr4:6,640,089–6,641,132 | 167.9 kb | Distal (>10kb) Multiome | 851 | |
| chr4:6,673,157–6,674,688 | 201.4 kb | Distal (>10kb) Multiome | 920 | |
| chr4:6,709,388–6,710,099 | 237.2 kb | Distal (>10kb) Multiome | 693 | |
| chr4:6,715,775–6,716,910 | 243.6 kb | Distal (>10kb) Multiome | 822 |
Genomic view of the PPP2R2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.