Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Involved in positive regulation of centriole elongation. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPP1R35. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R35 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R35, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,148,262–100,149,663 | 287.6 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 277.7 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 269.0 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,167,894–100,168,793 | 267.8 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 265.0 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 258.9 kb | Distal (>10kb) Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 169.7 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 165.8 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 164.2 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 100.4 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 54.4 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 7.5 kb | Proximal (<10kb) Multiome | 1296 | |
| chr7:100,431,643–100,432,380 | 4.1 kb | Proximal (<10kb) | 108 | |
| chr7:100,435,379–100,436,927 | 76 bp | At TSS Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 14.2 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 42.9 kb | Distal (>10kb) Multiome | 842 | |
| chr7:100,482,937–100,484,533 | 47.2 kb | Distal (>10kb) Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 102.6 kb | Distal (>10kb) Multiome | 858 | |
| chr7:100,542,221–100,542,986 | 106.2 kb | Distal (>10kb) Multiome | 274 | |
| chr7:100,569,177–100,570,642 | 133.2 kb | Distal (>10kb) Multiome | 855 | |
| chr7:100,585,161–100,587,241 | 149.9 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 175.8 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 190.3 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 219.9 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 237.0 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 239.4 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 255.4 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 257.9 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 269.5 kb | Distal (>10kb) Multiome | 962 |
Genomic view of the PPP1R35 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.