This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for PPM1E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPM1E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPM1E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:58,487,466–58,488,518 | 268.0 kb | Distal (>10kb) Multiome | 222 | |
| chr17:58,513,911–58,515,157 | 241.2 kb | Distal (>10kb) Multiome | 585 | |
| chr17:58,517,239–58,519,377 | 237.8 kb | Distal (>10kb) Multiome | 1140 | |
| chr17:58,527,884–58,528,411 | 227.7 kb | Distal (>10kb) Multiome | 79 | |
| chr17:58,531,392–58,532,430 | 223.8 kb | Distal (>10kb) Multiome | 323 | |
| chr17:58,630,482–58,632,252 | 124.1 kb | Distal (>10kb) Multiome | 1257 | |
| chr17:58,657,864–58,659,830 | 96.7 kb | Distal (>10kb) Multiome | 1269 | |
| chr17:58,669,900–58,670,548 | 85.6 kb | Distal (>10kb) Multiome | 52 | |
| chr17:58,678,911–58,679,743 | 76.3 kb | Distal (>10kb) Multiome | 889 | |
| chr17:58,692,284–58,692,956 | 63.2 kb | Distal (>10kb) Multiome | 1038 | |
| chr17:58,755,487–58,756,995 | 33 bp | At TSS Multiome | 682 | |
| chr17:60,037,145–60,037,598 | 1281.5 kb | Distal (>10kb) Multiome HiCAR | 592 |
Genomic view of the PPM1E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.