The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPM1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPM1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPM1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:43,995,542–43,996,864 | 172.7 kb | Distal (>10kb) Multiome | 909 | |
| chr2:44,044,245–44,044,695 | 124.4 kb | Distal (>10kb) Multiome | 537 | |
| chr2:44,086,758–44,087,671 | 81.6 kb | Distal (>10kb) Multiome | 648 | |
| chr2:44,166,185–44,166,382 | 2.5 kb | Proximal (<10kb) | 81 | |
| chr2:44,167,415–44,169,762 | 911 bp | At TSS Multiome | 1028 | |
| chr2:44,361,086–44,362,690 | 193.0 kb | Distal (>10kb) Multiome | 985 | |
| chr2:44,430,133–44,430,674 | 261.6 kb | Distal (>10kb) Multiome | 78 |
Genomic view of the PPM1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.