The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPFIA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPFIA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPFIA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:70,078,428–70,079,018 | 192.0 kb | Distal (>10kb) Multiome | 150 | |
| chr11:70,141,113–70,142,538 | 129.0 kb | Distal (>10kb) Multiome | 319 | |
| chr11:70,202,749–70,203,803 | 67.5 kb | Distal (>10kb) Multiome | 782 | |
| chr11:70,213,835–70,214,626 | 56.5 kb | Distal (>10kb) Multiome | 51 | |
| chr11:70,219,601–70,220,630 | 50.6 kb | Distal (>10kb) Multiome | 148 | |
| chr11:70,269,844–70,271,534 | 157 bp | At TSS Multiome | 790 | |
| chr11:70,397,703–70,399,001 | 127.7 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the PPFIA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.