POLR2L
RNA polymerase II, I and III subunit L | RBP10, RPABC5, RPB10beta, RPB7.6, hRPB7.6, hsRPB10b

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.10 Developmental clusters: GC1
Biological processes 37 terms
DNA binding (GO:0003677)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-templated transcription (GO:0006351)RNA polymerase I complex (GO:0005736)RNA polymerase I complex (GO:0005736)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)cytosol (GO:0005829)nucleolar large rRNA transcription by RNA polymerase I (GO:0042790)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of transcription by RNA polymerase I (GO:0006356)tRNA transcription by RNA polymerase III (GO:0042797)termination of RNA polymerase I transcription (GO:0006363)termination of RNA polymerase III transcription (GO:0006386)transcription by RNA polymerase I (GO:0006360)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase III (GO:0006383)transcription elongation by RNA polymerase I (GO:0006362)transcription elongation by RNA polymerase II (GO:0006368)transcription initiation at RNA polymerase I promoter (GO:0006361)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription initiation at RNA polymerase III promoter (GO:0006384)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)
Expression (TPM)
POLR2L — as a Regulated Gene

TFs regulating POLR2L 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to POLR2L

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:554,380–556,321 287.4 kb Distal (>10kb) Multiome 460
chr11:559,830–562,079 281.7 kb Distal (>10kb) Multiome 791
chr11:567,850–569,533 274.0 kb Distal (>10kb) Multiome 672
chr11:574,830–576,748 266.4 kb Distal (>10kb) Multiome 793
chr11:613,334–614,059 228.8 kb Distal (>10kb) Multiome 215
chr11:615,262–616,320 226.6 kb Distal (>10kb) Multiome 443
chr11:636,786–637,700 205.4 kb Distal (>10kb) Multiome 161
chr11:693,835–696,330 147.1 kb Distal (>10kb) Multiome 873
chr11:705,737–706,270 136.5 kb Distal (>10kb) Multiome 361
chr11:720,619–721,074 121.6 kb Distal (>10kb) Multiome 156
chr11:727,901–728,499 114.4 kb Distal (>10kb) Multiome 686
chr11:746,704–748,069 95.2 kb Distal (>10kb) Multiome 755
chr11:762,582–763,602 79.2 kb Distal (>10kb) Multiome 326
chr11:776,216–778,328 65.1 kb Distal (>10kb) Multiome 770
chr11:783,385–783,909 58.8 kb Distal (>10kb) Multiome 278
chr11:797,112–798,675 44.3 kb Distal (>10kb) Multiome 697
chr11:804,241–805,812 37.2 kb Distal (>10kb) Multiome 725
chr11:808,894–810,402 32.8 kb Distal (>10kb) Multiome 976
chr11:818,369–820,592 23.0 kb Distal (>10kb) Multiome 749
chr11:826,980–828,116 15.0 kb Distal (>10kb) Multiome 662
chr11:828,933–831,262 12.1 kb Distal (>10kb) Multiome 491
chr11:832,323–833,565 9.7 kb Proximal (<10kb) Multiome 562
chr11:842,034–843,556 170 bp At TSS Multiome 794
chr11:843,773–845,220 1.9 kb Proximal (<10kb) Multiome 664
chr11:848,377–848,758 5.8 kb Proximal (<10kb) 204
chr11:849,082–850,270 7.3 kb Proximal (<10kb) Multiome 229
chr11:910,337–911,591 68.4 kb Distal (>10kb) Multiome 754
chr11:925,038–926,264 83.3 kb Distal (>10kb) Multiome 689

Genome Browser

Genomic view of the POLR2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:544,380 – 936,264
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact