POLR1C

RNA polymerase I and III subunit C | AC40, RPA39, RPA40, RPA5, RPAC1, RPC40

The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Member of: DE-5 Developmental clusters: GC4

Biological processes 31 terms

DNA binding (GO:0003677)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-templated transcription (GO:0006351)RNA polymerase I complex (GO:0005736)RNA polymerase I complex (GO:0005736)RNA polymerase I complex (GO:0005736)RNA polymerase I complex (GO:0005736)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)fibrillar center (GO:0001650)nucleolar large rRNA transcription by RNA polymerase I (GO:0042790)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein dimerization activity (GO:0046983)termination of RNA polymerase I transcription (GO:0006363)termination of RNA polymerase III transcription (GO:0006386)transcription by RNA polymerase I (GO:0006360)transcription by RNA polymerase III (GO:0006383)transcription elongation by RNA polymerase I (GO:0006362)transcription initiation at RNA polymerase I promoter (GO:0006361)transcription initiation at RNA polymerase III promoter (GO:0006384)

Expression (TPM)

TFs regulating POLR1C 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLR1C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:43,228,982–43,229,794	287.6 kb	Distal (>10kb) Multiome HiCAR	918
chr6:43,246,576–43,247,616	269.9 kb	Distal (>10kb) Multiome	750
chr6:43,267,244–43,268,167	249.4 kb	Distal (>10kb) Multiome	772
chr6:43,285,054–43,285,508	231.8 kb	Distal (>10kb) Multiome	68
chr6:43,308,219–43,309,149	208.3 kb	Distal (>10kb) Multiome	462
chr6:43,368,714–43,370,143	147.4 kb	Distal (>10kb) Multiome	909
chr6:43,426,936–43,428,340	89.4 kb	Distal (>10kb) Multiome	919
chr6:43,454,362–43,454,991	62.4 kb	Distal (>10kb) Multiome	686
chr6:43,477,347–43,478,043	39.5 kb	Distal (>10kb) Multiome	747
chr6:43,506,605–43,507,204	10.2 kb	Distal (>10kb) Multiome	474
chr6:43,509,337–43,511,016	6.8 kb	Proximal (<10kb) Multiome	734
chr6:43,516,463–43,517,515	91 bp	At TSS Multiome	904
chr6:43,575,269–43,576,483	59.0 kb	Distal (>10kb) Multiome	1044
chr6:43,628,488–43,630,447	113.1 kb	Distal (>10kb) Multiome	1157
chr6:43,635,496–43,636,104	118.7 kb	Distal (>10kb) Multiome	941
chr6:43,644,712–43,645,902	128.2 kb	Distal (>10kb) Multiome	255
chr6:43,667,273–43,667,900	150.3 kb	Distal (>10kb) Multiome	625
chr6:43,667,997–43,668,873	151.3 kb	Distal (>10kb) Multiome	664
chr6:43,695,239–43,695,940	178.6 kb	Distal (>10kb) Multiome	207
chr6:43,702,335–43,703,403	185.9 kb	Distal (>10kb) Multiome	713
chr6:43,706,840–43,708,370	190.9 kb	Distal (>10kb) Multiome	307
chr6:43,739,421–43,740,065	222.7 kb	Distal (>10kb) Multiome	175
chr6:43,769,188–43,772,162	252.9 kb	Distal (>10kb) Multiome	1112
chr6:43,774,651–43,775,250	257.9 kb	Distal (>10kb) Multiome	440

Genome Browser

Genomic view of the POLR1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.