This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for POLA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:24,464,760–24,465,791 | 228.8 kb | Distal (>10kb) Multiome | 594 | |
| chrX:24,646,728–24,647,959 | 46.6 kb | Distal (>10kb) Multiome | 281 | |
| chrX:24,692,371–24,692,665 | 1.3 kb | Proximal (<10kb) | 61 | |
| chrX:24,693,333–24,694,220 | 172 bp | At TSS Multiome | 759 | |
| chrX:24,915,772–24,916,410 | 222.1 kb | Distal (>10kb) Multiome | 109 |
Genomic view of the POLA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.