Involved in spermatogenesis. Located in sperm head-tail coupling apparatus. Implicated in spermatogenic failure 31. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PMFBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PMFBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PMFBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:71,883,009–71,884,742 | 288.0 kb | Distal (>10kb) Multiome | 791 | |
| chr16:71,894,288–71,896,022 | 276.7 kb | Distal (>10kb) Multiome | 1139 | |
| chr16:71,981,752–71,982,390 | 190.1 kb | Distal (>10kb) Multiome | 263 | |
| chr16:72,008,426–72,009,172 | 163.5 kb | Distal (>10kb) Multiome | 815 | |
| chr16:72,013,585–72,014,228 | 158.1 kb | Distal (>10kb) Multiome | 263 | |
| chr16:72,093,288–72,094,355 | 78.4 kb | Distal (>10kb) Multiome | 860 | |
| chr16:72,111,833–72,112,319 | 60.0 kb | Distal (>10kb) Multiome | 60 | |
| chr16:72,162,164–72,162,652 | 9.5 kb | Proximal (<10kb) | 61 | |
| chr16:72,202,429–72,203,074 | 30.7 kb | Distal (>10kb) Multiome | 160 | |
| chr16:72,370,949–72,371,904 | 199.4 kb | Distal (>10kb) Multiome | 273 | |
| chr16:72,380,053–72,380,764 | 208.2 kb | Distal (>10kb) Multiome | 57 | |
| chr16:73,032,675–73,033,995 | 861.2 kb | Distal (>10kb) Multiome HiCAR | 364 |
Genomic view of the PMFBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.