Enables leucine zipper domain binding activity and transcription coactivator activity. Involved in chromosome segregation. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of MIS12/MIND type complex. Implicated in bladder carcinoma and urinary bladder cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PMF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PMF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PMF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:155,934,107–155,934,787 | 278.5 kb | Distal (>10kb) Multiome | 872 | |
| chr1:155,976,727–155,977,187 | 236.1 kb | Distal (>10kb) Multiome | 316 | |
| chr1:155,977,296–155,979,264 | 234.3 kb | Distal (>10kb) Multiome | 698 | |
| chr1:156,020,469–156,021,128 | 192.1 kb | Distal (>10kb) Multiome | 558 | |
| chr1:156,052,923–156,055,358 | 158.1 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:156,060,806–156,061,738 | 151.8 kb | Distal (>10kb) Multiome | 318 | |
| chr1:156,063,507–156,064,184 | 149.2 kb | Distal (>10kb) Multiome | 199 | |
| chr1:156,076,488–156,077,355 | 136.0 kb | Distal (>10kb) Multiome | 246 | |
| chr1:156,081,942–156,083,586 | 130.4 kb | Distal (>10kb) Multiome | 670 | |
| chr1:156,105,879–156,107,316 | 106.4 kb | Distal (>10kb) Multiome | 663 | |
| chr1:156,114,184–156,115,669 | 98.3 kb | Distal (>10kb) Multiome | 824 | |
| chr1:156,123,520–156,124,091 | 89.2 kb | Distal (>10kb) Multiome | 679 | |
| chr1:156,129,945–156,130,610 | 82.6 kb | Distal (>10kb) Multiome | 733 | |
| chr1:156,146,058–156,146,760 | 66.7 kb | Distal (>10kb) Multiome HiCAR | 429 | |
| chr1:156,149,593–156,150,242 | 63.0 kb | Distal (>10kb) Multiome HiCAR | 194 | |
| chr1:156,160,602–156,161,218 | 51.9 kb | Distal (>10kb) Multiome | 218 | |
| chr1:156,181,487–156,182,119 | 31.2 kb | Distal (>10kb) Multiome | 145 | |
| chr1:156,184,002–156,185,155 | 28.6 kb | Distal (>10kb) Multiome | 216 | |
| chr1:156,193,531–156,194,375 | 19.1 kb | Distal (>10kb) Multiome | 751 | |
| chr1:156,212,611–156,213,686 | 125 bp | At TSS Multiome | 893 | |
| chr1:156,217,914–156,218,159 | 4.9 kb | Proximal (<10kb) | 130 | |
| chr1:156,245,413–156,246,269 | 32.8 kb | Distal (>10kb) Multiome | 380 | |
| chr1:156,282,165–156,283,323 | 69.8 kb | Distal (>10kb) Multiome | 973 | |
| chr1:156,291,233–156,291,857 | 78.5 kb | Distal (>10kb) Multiome | 518 | |
| chr1:156,337,825–156,339,056 | 125.5 kb | Distal (>10kb) Multiome | 836 | |
| chr1:156,356,873–156,357,393 | 144.1 kb | Distal (>10kb) Multiome | 506 | |
| chr1:156,368,893–156,369,552 | 156.2 kb | Distal (>10kb) Multiome | 529 | |
| chr1:156,420,712–156,422,291 | 208.7 kb | Distal (>10kb) Multiome | 569 | |
| chr1:156,429,277–156,430,847 | 216.9 kb | Distal (>10kb) Multiome | 231 | |
| chr1:156,432,112–156,432,986 | 219.6 kb | Distal (>10kb) Multiome | 50 | |
| chr1:156,439,076–156,440,265 | 227.0 kb | Distal (>10kb) Multiome | 264 | |
| chr1:156,456,348–156,457,982 | 243.7 kb | Distal (>10kb) Multiome | 1033 | |
| chr1:156,499,927–156,501,599 | 288.0 kb | Distal (>10kb) Multiome | 950 | |
| chr1:156,504,626–156,505,685 | 292.3 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the PMF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.