This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020]
Transcription factors with Perturb-seq knockdown data for PMAIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PMAIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PMAIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:59,671,391–59,672,055 | 228.3 kb | Distal (>10kb) Multiome | 27 | |
| chr18:59,681,462–59,682,388 | 218.2 kb | Distal (>10kb) Multiome | 214 | |
| chr18:59,696,392–59,697,954 | 202.5 kb | Distal (>10kb) Multiome | 451 | |
| chr18:59,863,681–59,864,771 | 35.7 kb | Distal (>10kb) Multiome HiCAR | 281 | |
| chr18:59,897,268–59,897,851 | 2.1 kb | Proximal (<10kb) | 136 | |
| chr18:59,898,933–59,901,245 | 99 bp | At TSS Multiome | 872 | |
| chr18:59,904,759–59,905,409 | 4.8 kb | Proximal (<10kb) | 388 | |
| chr18:59,908,363–59,908,981 | 8.4 kb | Proximal (<10kb) | 94 | |
| chr18:59,937,643–59,938,291 | 37.9 kb | Distal (>10kb) Multiome | 187 | |
| chr18:61,790,226–61,791,865 | 1891.5 kb | Distal (>10kb) Multiome HiCAR | 169 | |
| chr18:61,892,652–61,895,395 | 1994.5 kb | Distal (>10kb) Multiome HiCAR | 584 |
Genomic view of the PMAIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.