Predicted to enable semaphorin receptor activity. Predicted to be involved in nervous system development; regulation of cell migration; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in membrane. Predicted to be part of semaphorin receptor complex. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PLXNA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLXNA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLXNA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:131,691,912–131,692,612 | 885.0 kb | Distal (>10kb) Multiome HiCAR | 352 | |
| chr7:132,318,654–132,319,274 | 258.3 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr7:132,456,344–132,456,882 | 120.7 kb | Distal (>10kb) Multiome | 140 | |
| chr7:132,475,108–132,476,093 | 101.5 kb | Distal (>10kb) Multiome HiCAR | 120 | |
| chr7:132,536,943–132,537,867 | 39.8 kb | Distal (>10kb) Multiome | 66 | |
| chr7:132,575,506–132,577,965 | 140 bp | At TSS Multiome | 307 | |
| chr7:132,580,755–132,581,203 | 4.3 kb | Proximal (<10kb) | 232 | |
| chr7:132,591,904–132,593,477 | 15.8 kb | Distal (>10kb) Multiome | 151 | |
| chr7:132,614,538–132,615,559 | 37.7 kb | Distal (>10kb) Multiome | 182 | |
| chr7:132,687,966–132,688,446 | 110.9 kb | Distal (>10kb) Multiome | 112 | |
| chr7:134,126,989–134,127,843 | 1550.1 kb | Distal (>10kb) Multiome HiCAR | 460 | |
| chr7:134,432,345–134,433,248 | 1855.4 kb | Distal (>10kb) Multiome HiCAR | 622 |
Genomic view of the PLXNA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.