This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses. [provided by RefSeq, May 2022]
Transcription factors with Perturb-seq knockdown data for PLSCR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLSCR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLSCR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:146,250,453–146,251,614 | 293.7 kb | Distal (>10kb) Multiome | 541 | |
| chr3:146,404,722–146,405,822 | 139.5 kb | Distal (>10kb) Multiome | 141 | |
| chr3:146,468,944–146,470,088 | 75.2 kb | Distal (>10kb) Multiome | 488 | |
| chr3:146,522,213–146,523,383 | 21.9 kb | Distal (>10kb) Multiome | 255 | |
| chr3:146,543,029–146,543,278 | 1.4 kb | Proximal (<10kb) | 29 | |
| chr3:146,543,832–146,545,051 | at TSS | At TSS Multiome | 819 | |
| chr3:146,554,261–146,554,844 | 9.5 kb | Proximal (<10kb) | 183 |
Genomic view of the PLSCR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.