Enables diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLPP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLPP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLPP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:38,015,136–38,015,926 | 253.7 kb | Distal (>10kb) Multiome | 59 | |
| chr8:38,029,913–38,031,249 | 238.7 kb | Distal (>10kb) Multiome | 948 | |
| chr8:38,066,984–38,067,582 | 202.0 kb | Distal (>10kb) Multiome | 414 | |
| chr8:38,070,928–38,072,232 | 197.5 kb | Distal (>10kb) Multiome | 282 | |
| chr8:38,104,797–38,106,255 | 163.5 kb | Distal (>10kb) Multiome | 954 | |
| chr8:38,108,727–38,109,662 | 160.1 kb | Distal (>10kb) Multiome | 83 | |
| chr8:38,175,948–38,177,501 | 92.5 kb | Distal (>10kb) Multiome | 870 | |
| chr8:38,230,935–38,232,445 | 37.6 kb | Distal (>10kb) Multiome | 904 | |
| chr8:38,268,159–38,269,673 | 68 bp | At TSS Multiome | 795 | |
| chr8:38,381,367–38,383,496 | 113.1 kb | Distal (>10kb) Multiome | 956 | |
| chr8:38,385,791–38,387,334 | 117.2 kb | Distal (>10kb) Multiome | 816 | |
| chr8:38,440,285–38,442,102 | 171.7 kb | Distal (>10kb) Multiome | 293 | |
| chr8:38,442,374–38,442,980 | 173.4 kb | Distal (>10kb) Multiome | 254 | |
| chr8:38,467,549–38,469,321 | 199.5 kb | Distal (>10kb) Multiome | 775 | |
| chr8:38,471,859–38,472,443 | 203.0 kb | Distal (>10kb) Multiome | 84 | |
| chr8:38,512,281–38,512,945 | 243.3 kb | Distal (>10kb) Multiome | 187 | |
| chr8:38,513,847–38,514,352 | 244.8 kb | Distal (>10kb) Multiome | 185 | |
| chr8:38,530,520–38,531,118 | 261.8 kb | Distal (>10kb) Multiome | 174 | |
| chr8:38,541,080–38,541,513 | 272.0 kb | Distal (>10kb) Multiome | 114 | |
| chr8:38,553,735–38,554,545 | 284.8 kb | Distal (>10kb) Multiome | 413 | |
| chr8:38,566,934–38,567,642 | 298.1 kb | Distal (>10kb) Multiome | 337 |
Genomic view of the PLPP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.