The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PLPP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLPP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLPP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:289,719–291,481 | 858 bp | At TSS Multiome | 412 | |
| chr19:291,654–291,999 | 272 bp | At TSS | 148 | |
| chr19:294,836–295,426 | 3.9 kb | Proximal (<10kb) Multiome | 231 | |
| chr19:343,939–345,411 | 53.4 kb | Distal (>10kb) Multiome | 600 | |
| chr19:408,569–409,459 | 117.7 kb | Distal (>10kb) Multiome | 310 | |
| chr19:459,789–461,382 | 168.8 kb | Distal (>10kb) Multiome | 545 | |
| chr19:461,557–462,453 | 170.7 kb | Distal (>10kb) Multiome | 580 | |
| chr19:488,399–489,918 | 197.7 kb | Distal (>10kb) Multiome | 898 | |
| chr19:506,451–508,366 | 215.8 kb | Distal (>10kb) Multiome | 1001 | |
| chr19:510,509–511,797 | 219.5 kb | Distal (>10kb) Multiome | 739 | |
| chr19:518,865–519,356 | 227.7 kb | Distal (>10kb) Multiome | 151 | |
| chr19:530,809–533,397 | 240.0 kb | Distal (>10kb) Multiome | 856 | |
| chr19:572,071–573,594 | 281.1 kb | Distal (>10kb) Multiome | 888 | |
| chr19:588,127–589,976 | 296.9 kb | Distal (>10kb) Multiome | 526 |
Genomic view of the PLPP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.