Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLBD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLBD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLBD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:14,267,660–14,268,650 | 299.7 kb | Distal (>10kb) Multiome | 60 | |
| chr12:14,365,285–14,366,175 | 202.1 kb | Distal (>10kb) Multiome | 680 | |
| chr12:14,567,263–14,568,383 | 86 bp | At TSS Multiome | 366 | |
| chr12:14,570,356–14,570,554 | 2.5 kb | Proximal (<10kb) | 4 | |
| chr12:14,710,018–14,711,213 | 142.8 kb | Distal (>10kb) Multiome | 148 | |
| chr12:14,768,991–14,772,177 | 202.0 kb | Distal (>10kb) Multiome | 1151 | |
| chr12:14,773,514–14,775,433 | 206.4 kb | Distal (>10kb) Multiome | 550 | |
| chr12:14,802,974–14,804,269 | 235.7 kb | Distal (>10kb) Multiome | 702 |
Genomic view of the PLBD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.