Enables protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin protein ligase activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of macrophage activation; and regulation of signal transduction. Located in centriolar satellite; cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PJA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PJA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PJA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:108,380,379–108,383,211 | 1027.7 kb | Distal (>10kb) Multiome HiCAR | 1127 | |
| chr5:109,406,064–109,406,379 | 3.6 kb | Proximal (<10kb) | 17 | |
| chr5:109,409,009–109,411,131 | 205 bp | At TSS Multiome | 991 | |
| chr5:109,413,008–109,413,823 | 3.0 kb | Proximal (<10kb) | 165 | |
| chr5:109,530,383–109,531,349 | 121.0 kb | Distal (>10kb) Multiome | 123 | |
| chr5:109,688,464–109,691,494 | 279.5 kb | Distal (>10kb) Multiome | 1024 |
Genomic view of the PJA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.