This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded cytoplasmic protein plays a role in multiple processes including cell signaling and lipid metabolism by facilitating the transfer of phosphatidylinositol between membrane compartments. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for PITPNC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PITPNC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PITPNC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:67,244,560–67,246,439 | 133.0 kb | Distal (>10kb) Multiome | 883 | |
| chr17:67,246,551–67,247,087 | 132.0 kb | Distal (>10kb) Multiome | 607 | |
| chr17:67,290,779–67,291,459 | 87.8 kb | Distal (>10kb) Multiome | 168 | |
| chr17:67,322,116–67,322,669 | 56.6 kb | Distal (>10kb) Multiome | 109 | |
| chr17:67,334,311–67,335,152 | 44.2 kb | Distal (>10kb) Multiome | 133 | |
| chr17:67,366,174–67,366,796 | 12.3 kb | Distal (>10kb) Multiome | 985 | |
| chr17:67,374,722–67,375,099 | 2.2 kb | Proximal (<10kb) | 413 | |
| chr17:67,376,724–67,379,389 | 1.7 kb | Proximal (<10kb) Multiome | 959 | |
| chr17:67,717,249–67,718,509 | 338.9 kb | Distal (>10kb) Multiome HiCAR | 991 | |
| chr17:67,752,011–67,752,512 | 373.4 kb | Distal (>10kb) Multiome HiCAR | 77 |
Genomic view of the PITPNC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.