Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within phosphatidylinositol biosynthetic process. Located in uropod. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PIP5K1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIP5K1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIP5K1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:68,417,697–68,418,944 | 286.8 kb | Distal (>10kb) Multiome | 118 | |
| chr9:68,704,523–68,706,504 | 13 bp | At TSS Multiome | 702 | |
| chr9:68,755,540–68,756,160 | 50.7 kb | Distal (>10kb) Multiome | 164 | |
| chr9:68,779,458–68,780,758 | 74.8 kb | Distal (>10kb) Multiome | 827 | |
| chr9:68,871,983–68,872,511 | 167.1 kb | Distal (>10kb) Multiome | 208 | |
| chr9:68,894,403–68,895,261 | 189.6 kb | Distal (>10kb) Multiome | 84 | |
| chr9:69,035,618–69,036,298 | 330.7 kb | Distal (>10kb) Multiome HiCAR | 819 |
Genomic view of the PIP5K1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.