This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for PIN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:71,910,545–71,912,028 | 270.3 kb | Distal (>10kb) Multiome | 258 | |
| chrX:71,957,980–71,958,453 | 223.6 kb | Distal (>10kb) Multiome | 90 | |
| chrX:72,018,244–72,018,883 | 163.0 kb | Distal (>10kb) Multiome | 577 | |
| chrX:72,115,329–72,115,816 | 66.1 kb | Distal (>10kb) Multiome | 75 | |
| chrX:72,131,595–72,132,294 | 49.7 kb | Distal (>10kb) Multiome | 266 | |
| chrX:72,181,219–72,182,040 | 127 bp | At TSS Multiome | 619 | |
| chrX:72,238,686–72,239,464 | 57.4 kb | Distal (>10kb) Multiome | 448 | |
| chrX:72,276,823–72,277,642 | 95.6 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the PIN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.