Enables several functions, including enzyme binding activity; histone binding activity; and phosphoprotein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and protein-containing complex assembly. Located in cytoplasm and nucleolus. Part of R2TP complex; RPAP3/R2TP/prefoldin-like complex; and pre-snoRNP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PIH1D1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIH1D1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIH1D1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,151,539–49,152,548 | 299.8 kb | Distal (>10kb) Multiome | 497 | |
| chr19:49,157,555–49,158,336 | 294.0 kb | Distal (>10kb) Multiome | 599 | |
| chr19:49,210,032–49,211,225 | 241.3 kb | Distal (>10kb) Multiome | 366 | |
| chr19:49,337,997–49,340,482 | 112.6 kb | Distal (>10kb) Multiome | 612 | |
| chr19:49,361,283–49,362,837 | 90.2 kb | Distal (>10kb) Multiome | 553 | |
| chr19:49,362,970–49,364,306 | 88.1 kb | Distal (>10kb) Multiome | 616 | |
| chr19:49,403,611–49,404,247 | 47.9 kb | Distal (>10kb) Multiome | 305 | |
| chr19:49,432,343–49,432,785 | 19.3 kb | Distal (>10kb) Multiome | 103 | |
| chr19:49,436,149–49,436,821 | 15.3 kb | Distal (>10kb) Multiome | 248 | |
| chr19:49,441,067–49,441,861 | 10.3 kb | Distal (>10kb) Multiome | 223 | |
| chr19:49,442,072–49,444,054 | 8.9 kb | Proximal (<10kb) Multiome | 914 | |
| chr19:49,447,537–49,447,812 | 4.0 kb | Proximal (<10kb) | 105 | |
| chr19:49,451,347–49,452,239 | 31 bp | At TSS Multiome | 764 | |
| chr19:49,452,723–49,453,850 | 1.6 kb | Proximal (<10kb) Multiome | 847 | |
| chr19:49,476,063–49,476,551 | 24.6 kb | Distal (>10kb) Multiome | 244 | |
| chr19:49,487,027–49,488,279 | 35.6 kb | Distal (>10kb) Multiome | 964 | |
| chr19:49,495,613–49,496,661 | 44.4 kb | Distal (>10kb) Multiome | 919 | |
| chr19:49,500,403–49,501,353 | 48.9 kb | Distal (>10kb) Multiome | 405 | |
| chr19:49,512,565–49,513,700 | 61.3 kb | Distal (>10kb) Multiome | 655 | |
| chr19:49,527,651–49,528,221 | 76.1 kb | Distal (>10kb) Multiome | 354 | |
| chr19:49,533,232–49,534,476 | 82.2 kb | Distal (>10kb) Multiome | 534 | |
| chr19:49,555,629–49,557,180 | 104.3 kb | Distal (>10kb) Multiome | 294 | |
| chr19:49,580,125–49,580,813 | 128.8 kb | Distal (>10kb) Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 141.7 kb | Distal (>10kb) Multiome | 994 | |
| chr19:49,638,063–49,638,728 | 186.5 kb | Distal (>10kb) Multiome | 237 | |
| chr19:49,639,671–49,642,787 | 188.6 kb | Distal (>10kb) Multiome | 1067 | |
| chr19:49,664,165–49,665,096 | 212.7 kb | Distal (>10kb) Multiome | 679 | |
| chr19:49,665,345–49,666,430 | 214.1 kb | Distal (>10kb) Multiome | 721 | |
| chr19:49,672,105–49,672,787 | 220.6 kb | Distal (>10kb) Multiome | 625 | |
| chr19:49,676,058–49,678,754 | 225.1 kb | Distal (>10kb) Multiome | 1033 | |
| chr19:49,680,433–49,681,147 | 229.0 kb | Distal (>10kb) Multiome | 435 | |
| chr19:49,690,485–49,691,761 | 239.3 kb | Distal (>10kb) Multiome | 327 | |
| chr19:49,746,188–49,746,748 | 294.7 kb | Distal (>10kb) Multiome | 283 |
Genomic view of the PIH1D1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.