Enables histone binding activity. Predicted to be involved in several processes, including germinal center B cell differentiation; lung development; and negative regulation of mesenchymal cell proliferation involved in lung development. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHF14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHF14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHF14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:10,908,250–10,909,344 | 64.6 kb | Distal (>10kb) Multiome | 207 | |
| chr7:10,939,396–10,941,296 | 33.0 kb | Distal (>10kb) Multiome | 1007 | |
| chr7:10,972,785–10,974,913 | 425 bp | At TSS Multiome | 896 | |
| chr7:10,975,796–10,976,412 | 2.5 kb | Proximal (<10kb) | 68 | |
| chr7:11,193,012–11,194,168 | 220.2 kb | Distal (>10kb) Multiome | 384 | |
| chr7:11,234,831–11,236,097 | 262.3 kb | Distal (>10kb) Multiome | 97 |
Genomic view of the PHF14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.